Danger Mouse arrives in ancient Greece and befriends Zeus, who grants him godly powers.
Danger Mouse is left gadget-less when an unappreciated Squawk leaves the Danger Agency to work for tech genius Elon Muskrat.
Penfold takes a trip inside Danger Mouse's body to save him from a deadly aversion to his own heroism.
The danger agents are at Squawk's super-secret Wild West testing facility, home to a society of Penbots, robots who have a rather familiar face. Squawk is sure she's improved upon Penfold and made the perfect robotic sidekick for Danger Mouse, Tenfold. But Tenfold malfunctions and transforms into the ruthless Meanfold, determined to destroy anyone who's not quite perfect.
Danger Mouse and Penfold are celebrating another noisy victory, gleefully ringing Big Ben's bell when an over-excited Penfold falls, pushing the clock hand forward, causing the sun to go down prematurely. Unbeknownst to them a mysterious figure watches on from nearby noting the clock's incredible time-controlling powers. When DM realises that the day is being stolen and replaced with a silent night, he enlists the help of expert colleagues - the night shift! With Danger Moth and Danger Mole in tow the team track the quiet culprit. But a noisy Danger Mouse might just be outwitted by this stealthy saboteur.
Baron Greenback brews a plot to steal every beverage on the planet, mix them all together, making an un-drinkable disgusting sludge. By depriving the population of their much-needed drinks break he'll cause worldwide exhaustion. Danger Mouse seems unfazed, but without his cherished tea Penfold wilts on their rescue mission. Can Danger Mouse thwart the Baron's thirsty plot?
A mishap on a mission leaves Danger Mouse confused - why is Penfold not talking to him? It might be because today is Penfold's birthday and he hasn't remembered it again! Squawk sprays DM with her experimental empathy gas in the hope that he will find it easier to care about other people. The newly empathetic DM is a changed mouse! One who seems to think breaking the Baron out of prison is a great idea.
Danger Mouse's over-reliance on gadgets prompts Colonel K to send his top agent on a tech-free nature retreat. Unbeknownst to Danger Mouse, Greenback has the same plans for his daughter, Delilah, whose social media obsession has also spiralled out of control. Back at HQ Penfold is tasked with protecting the entire world from the threat of super-villainy. Stripped off his gadgets, DM struggles to adapt to life in the wilderness and, when a talking pine cone called Conni begins to offer him survival tips, he begins to question his own sanity. Soon enough, Delilah catches wind of DM's presence and she plots to destroy him as a means of getting back into her Dad's good books.
The Snowman is hired as Danger Mouse's new sidekick, leaving Penfold without a job.
There's relief all around when Penfold's pilfering of Squawk's gadgets and clandestine late night trips to shady warehouses turns out to preparation for his taking part in 'bot battles' - a fight club for homemade robots. Penfold hopes to enter his own creation, Geoff, into the competition but is sidelined by an overeager Danger Mouse and his own robot, the CRN 3000! When the CRN 3000 obliterates all challengers, DM's call for a worthy opponent is answered by Megahurtz. But Megahurtz may have a secret android army agenda...
Danger Mouse and Penfold are in a training simulation when one of DM's flying kicks damages the holodeck with catastrophic consequences. They wake to find they've been in a three-year dream, that they aren't secret agents and work in IT instead, and the Danger Agency has been a figment of their imaginations! Whilst Penfold and Squawk quickly settle into a life of menial office work, DM struggles to accept life as Dane G Mouse.
Danger Mouse and Penfold must travel to the Twystyverse to stop Baron Silas von Penfold from taking over both versions of the Earth.